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7% vs. 41.9%, p=0.007; and median hospital stay (day) 21 vs. 27, p=0.005. The subsequent 142 patients showed 92% (131/142) applicability of EDR and 5.6% (8/142) incidence of CR-POPF. CONCLUSIONS Our new criteria for EDR, without DFA, enabled ≥90% applicability of EDR and reduced CR-POPF. This article is protected by copyright. All rights reserved.Telomeric repeat-containing RNA (TERRA) is closely involved in the regulation of telomere length, which plays critical role in tumorigenesis. However, the biological significance of TERRA in h

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Mechanistic analysis indicated that knockdown of FTO facilitated CoCl2-induced apoptosis via caspase activation and G1/S cell cycle arrest. Nevertheless, overexpression of FTO partly attenuated the increased apoptosis following CoCl2 exposure. More notably, we observed that FTO regulated apoptosis in an m6A-dependent manner. Therefore, our findings reveal that CoCl2 induced ROS affected the m6A modification of apoptosis-related genes by decreasing the expression of FTO, thereby resulting in the activation of apoptosis. These findings p