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We will report all adverse events observed in the included trials by sharing deidentified data and summary tables on the Open Science Framework (https//osf.io/w8puv/). Additionally, we will produce a summary report that describes differences between the randomised groups in each trial and across trials for prespecified harms outcomes. We will use secondary data. This study was determined to be exempt from Institutional Review Board (IR review (protocol #1910607198). We will use secondary data. This study was determined to