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Apoptotic cells were enumerated using a horse validated TUNEL technique. Compared to controls, significant increases in apoptotic cell counts were not detected in lamellar epithelial cells during the developmental phase or at the onset of lameness during laminitis induction. A negative correlation between apoptosis and leukocyte infiltration was detected in the BWE model (P  less then  0.05). In conclusion, apoptosis does not play an important role in the initial stages of sepsis-related laminitis.Oral probiotics are used to induce