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It was observed that leiomyosarcoma was more intensely stained with ZEB1 than leiomyoma (P  less then  0.001) and high-grade ESS was significantly more intensely stained with ZEB1 protein than low-grade ESS (P  less then  0.004). It also was observed that high-grade leiomyosarcoma was significantly more intensely stained with ZEB1 protein than low-grade leiomyosarcoma (P  less then  0.00. Our data suggest that Zeb1 can be used to differentiate high-grade sarcomas from their low-grade counterparts as well as benign and malignan