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Analysed data from 196 patients showed 46.3% of patients received corticosteroids. Steroid administration due to irAEs did not affect overall survival (OS) (p=0.38) compared with the steroid naïve group. Only steroid administration for the palliation of cancer-related symptoms was an independent predictor for shorter OS (HR=2.7; 95% CI, 1.5-4.9). The timeline of steroid administration did not affect OS (p=0.456) in our cohort. Steroids due to irAEs do not appear to hamper ICI efficacy. However, the administration of high-dose ste