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Where to Buy a French Bulldog Nearby French Bulldogs are low-maintenance dogs who love spending time with their owners. They are intelligent and eager to please, which makes them easy to train. However, they are free thinkers and can be stubborn. They are susceptible to certain health issues, such as breathing problems and skin fold infections. They are not suitable for swimming and should be kept away from water bodies. Reputable Breeders The French Bulldo

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Langerhans cells (LC), the dendritic cells of the epidermis, are distributed in a distinctive regularly spaced array. In the mouse, the LC array is established in the first few days of life from proliferating local precursors, but the regulating signaling pathways are not fully understood. We found that mice lacking the kinase phosphoinositide-dependent kinase 1 selectively lack LC. Deletion of the phosphoinositide-dependent kinase 1 target kinases, ribosomal S6 kinase 1 (Rsk1) and Rsk2, produced a striking perturbation in t