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2±24.7min vs 19.7±21.7min; p=0.03), and decreased the obstructive apnea index (OAI) (0 vs 8.7±18.8; p=0.01). Lower mean HR (66.6±4.1 bpm vs 70.6±5.9 bpm; p=0.03) and lower maximum HR (84.1±7.3 bpm vs 91.6±7.8 bpm; p=0.03) were observed in PSG with NIV. The use of NIV in patients with moderate to severe stable COPD while they were sleeping increased REM sleep time and decreased sleep onset latency, the number of obstructive respiratory events, and the mean and maximum HR. The use of NIV in patients with moderate to severe stable COPD whil

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The recruitment of RNA changes the material properties of condensates by hardening the condensate body. Moreover, the condensate size scales with RNA surface density; the higher the RNA density is, the smaller and more frequent the condensates are. These results suggest a mechanism based on physical constraints, provided by RNAs at the condensate surface, that limit condensate growth and coalescence.Multi-component phase separation is emerging as a key mechanism for the formation of biological condensates that play essential roles in s