https://www.selleckchem.com/pr....oducts/gsk1120212-jt
The effects of PDGFR-β inhibitor and PI3K inhibitor were observed. Compared with group CON, group IMA, and group LY294002, α-SMA was upregulated in group PDGF-BB (p 0.05), with higher OD490 nm value (p 0.05), narrower average scratch width, and higher relative cell migration rate (p 0.05). The expression levels of Col I, p-PDGFR-β, p-PI3K, and p-AKT were higher in group PDGF-BB (p 0.05). PDGF-BB induces FB to transform into myofibroblasts (MF through the PDGFR-β/PI3K/AKT signaling pathway, and promotes the

https://www.selleckchem.com/ph....armacological_epigen
Cell death is a common and active process that is involved in various biological processes, including organ development, morphogenesis, maintaining tissue homeostasis and eliminating potentially harmful cells. Abnormal regulation of cell death significantly contributes to tumor development, progression and chemoresistance. The mechanisms of cell death are complex and involve not only apoptosis and necrosis but also their cross-talk with other types of cell death, such as autophagy and the newly identified ferroptosis. Cancer