https://www.selleckchem.com/pr....oducts/AZD2281(Olapa
These results suggest that corrole 3 and Ga3 are promising candidates for use in the photodynamic therapy of breast cancer.Understanding how making structural changes in small molecules affects their binding affinities for targeted proteins is central to improving strategies for rational drug design. To assess the effects of varying the nature of nonpolar groups upon binding entropies and enthalpies, we designed and prepared a set of Grb2-SH2 domain ligands, Ac-pTyr-Ac6c-Asn-(CH2)n-R, in which the size and electrostatic nature

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