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1-fold) and GBA-PD patients (by 1.6-fold) (p less then 0.0001 and p less then 0.0001, respectively). GD macrophage treatment resulted in increased GCase level and increased enzyme colocalization with the lysosomal marker LAMP2. The possible binding modes of ambroxol to mutant GCase carrying N370S amino acid substitution at pH 4.7 were examined using molecular docking and molecular dynamics simulations. The ambroxol position characterized by minimal binding free energy was observed in close vicinity to the residue, at position 370. Taken

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The dwelling processes 2D metallicity in a strong 3D network. Additionally, hardness and electron-phonon calculations reveal that t-B2C3N2 is superhard and superconductive with a superconducting important temperature achieving 2.3 K.Changing the electric structure of materials by force plus the associated changes in optical properties have attracted medical interest. We've stated that the power position of the conduction band (C base while the crystal field