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33 at the extracellular face of TM7, causing transition to a more hydrophobic environment. The fluorescent moiety IAEDANS was site-specifically introduced at the intracellular end of TM6 (residue 2316.33) to report on the dynamic cytoplasmic face of the A2AR. The inverse agonist ZM241385 caused a concentration-dependent increase in fluorescence emission as the IAEDANS moved to a more hydrophobic environment, consistent with closing the G-protein binding crevice. NECA generated only 30% of the effect of ZM241385. This study pr

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Symptoms of ADHD in Adults Many people who suffer from ADHD endure their entire lives, without ever being diagnosed. They could be mistakenly diagnosed with other conditions. They may be at peace knowing that they are not 'lazy or unwilling'. They might also be frustrated that their problems were not identified and treated earlier. 1. Inattention and lack of Focus ADHD is often characterized by difficulty staying