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The content of IL-1β and IL-4 in such children fluctuates more compared to somatically healthy children. In conclusion, a violation of the local protective mechanisms of the oral cavity is observed in children with diffuse nontoxic goiter. Also, the increase in the severity of dental pathology leads to increased tension of local protective and compensatory reactions. ©Carol Davila University Press.The frequency of legislation changes and their utility is a subject of interest and always under debate with pro and contra argument